In a globalized economy where work is increasingly tenuous, the safety, health, and well-being of workers has become a matter of some urgency for organizational leaders, and an area of intense focus for researchers and practitioners.The Total Worker Health® initiative of the National Institute for Occupational Safety and Health (NIOSH), targets policies, programs, and practices that address risks to worker safety, health and well-being in both the physical and organizational work environment, as well as beyond the workplace.Chapters in this book cover organizational approaches for implementing integrative prevention programs for addressing these problems. This includes applications for diverse worker populations, such as workers in healthcare settings, construction, corrections, and manufacturing; for aging workers who may have multiple chronic health conditions; and, for workers employed in small businesses.Chapters also provide evidence of program effectiveness for addressing work conditions that impact mental health, fatigue and sleep, and work-life conflict.This volume is for occupational safety and health professionals, human resource managers, policymakers, and organizational trailblazers who understand that ensuring the safety, health, and well-being of workers is an essential best business practice.